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谷歌Gemma下载量破10亿次 AI深度探索癌症治疗新机制_我的网站

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    Illustration: Liu Rui/GTUS Pentagon official Elbridge Colby's latest Manila speech, in which he called on allies to "invest more" in their own defense and stressed that Washington wants "partners, not protectorates," has drawn attention from some Philippine media. Colby's claims also expose the fragility of the Manila-Washington alliance and Washington's push to enlist "Indo-Pacific" allies in serving its own strategic interests, a Chinese expert said, warning that the Philippines, by placing itself on the front line of provocations against China, risks being a geopolitical pawn left to bear the consequences on its own.
While delivering a speech at the Stratbase Institute in Manila, Philippines, on Monday, Colby, the Under Secretary of War for Policy, laid out the US' so-called "flexible realism" approach to the Indo-Pacific, stressing that the US is "definitely not disengaging from Asia" but strengthening its forward posture and seeking to build a "denial defense" along the First Island Chain, according to a transcript of the speech released on the US Department of War website.
At the same time, he called on US allies and partners to step up, invest more in their own defense, and take responsibility for their own sovereign security. "We are looking for partners, not protectorates," Colby claimed.
The claims have drawn attention from some Philippine media outlets, with some linking them to the South China Sea issue. However, the transcript of Colby's speech showed that he did not mention China, the Global Times found. 
A Manila Bulletin report noted that after calling on allies to invest more in defense, Colby cited the Philippines as an example of the "kind of partner Washington wants to work with." He praised Manila for "strengthening its military and coast guard capabilities while deepening operational cooperation with the US" amid what the report described as China's "aggression" in the South China Sea.
Colby's visit to Manila marked his first official trip to Southeast Asia as an undersecretary under the Trump administration. He is scheduled to travel from Manila to Jakarta, Indonesia; Bangkok, Thailand; and Phnom Penh, Cambodia, said the report.
Meanwhile, a Manila Standard report interpreted Colby's remarks as showing that "the US is working closely with the Philippines" to strengthen Manila's military capabilities and protect its sovereign rights in the South China Sea, despite the fact that Colby did not mention China in his speech.
The US appears to be adopting a more retrenchment-style approach, shifting from leading directly to relying on regional allies to take the frontline role while providing support. This approach allows Washington to advance its interests while lowering its own costs, Song Zhongping, a Chinese military affairs expert, told the Global Times.
Song noted that Washington seeks to use repeated maritime frictions to tie down Chinese resources, which helps explain Colby's praise for Manila: the Philippines bears part of Washington's strategic burden while receiving largely rhetorical US support.
A South China Morning Post report on Tuesday noted that Colby avoided mentioning the recent disputes over Huangyan Dao, despite Washington having criticized China's establishment of a nature reserve there just two days earlier. The report described the omission as a "measured tone" ahead of a potential meeting between the Chinese and US leaders.
Washington's primary concern is its own interests. At the core of its "Indo-Pacific strategy" is strengthening its alliance network by pushing partners such as the Philippines to shoulder greater security burdens in pursuit of US strategic goals. As US-China diplomatic dynamics evolve, countries serving as Washington's geopolitical spearheads in confrontations with China risk being left behind, said some observers.
Song noted that this also reveals the fragility of the US-Philippine relationship.
The US has encouraged the Philippines to take the front line in confrontations with China while offering mostly rhetorical support. Should tensions escalate, Manila would bear much of the cost on its own, said the expert. 
。    　　当地时间8月20日，谷歌宣布，其开源端侧模型家族Gemma的总下载量已突破10亿次。这款由谷歌DeepMind推出的开源大模型，自发布以来，全球开发者基于它衍生出超10万个定制变体，形成名为“Gemmaverse”的开源生态。
　　谷歌列举了多个Gemma家族应用场景：从太空本地图像分析、医疗报告标准数字化、癌症创新治疗方案再到动物语言识别，Gemma家族模型正实实在在地应用到各个垂直行业。　　其中，以Gemma为基座的模型在生物医药科研领域产出了多项标志性成果。谷歌一方面推出面向医疗场景的垂直模型MedGemma，支撑医疗报告结构化、医学影像辅助分析等应用；另一方面联合科研机构，依托Gemma底座攻坚癌症机制研究。　　其中最受行业关注的是谷歌DeepMind、谷歌研究院与耶鲁大学合作开发的Cell2Sentence-Scale 27B（C2S-Scale）模型。　　传统的癌症疫苗治疗思路，是让免疫系统通过识别身份标签来识别敌人。但这面临一个“瞄准困境”：一般来说，肿瘤的“身份标签”取自肿瘤本身,但很多肿瘤细胞表面缺少能被免疫T细胞识别的、独特的“身份标签”（即肿瘤特异性抗原），同时，它们还主动穿上“防护服”（如高表达PD-L1蛋白），成为所谓的“冷肿瘤”。结果就是，对于“冷肿瘤”，免疫系统即使大军压境，也像得了“脸盲症”，看不见敌人，或者看见了也被强行抑制，导致治疗无效。　　针对免疫治疗难以起效的“冷肿瘤”难题，C2S-Scale按活跃程度排序，将单细胞基因表达数据转化为类文本的“基因句子”，让大语言模型能直接“读”懂细胞。随后，该模型完成4000余种药物的虚拟筛选，预测出silmitasertib联合低剂量干扰素的用药组合。　　C2S-Scale锁定的候选药物中，仅10%-30%在过往文献中被提及，其余与筛选目标无已知关联。最终被选中的是silmitasertib（CX-4945），一种CK2激酶抑制剂。　　这一AI提出的全新治疗假说，后续在人源活细胞实验中得到验证，研究团队用模型训练时从未见过的人类神经内分泌细胞进行实验，结果是单独用药无效果，单用低剂量干扰素只有轻微提升，两者联用后抗原呈递提升约50%，证实联用方案可显著提升抗原呈递水平，属于少数AI产出全新癌症治疗机制并获得实验室验证的案例，有望提升肿瘤细胞抗原呈递能力，把冷肿瘤转化为对免疫治疗敏感的热肿瘤。　　该模型相关成果已对外开源，可供全球科研团队继续拓展研究。需要注意的是，该发现目前仅停留在体外细胞实验阶段，尚未进入临床。　　随着下载量冲高，Gemma证明开源大模型不再局限对话生成，能够直接介入原始生物数据挖掘，深度探索癌症治疗新机制，为AI医药科研提供低成本的技术底座。（文章来源：科创板日报）。

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